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Protective role of neutrophils in mice experimentally infected with Rhodococcus equi
Ronald J Martens1, Noah D Cohen, Samuel L Jones
1Equine Infectious Disease Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, 77843, USA. rmartens@cvm.tamu.edu
Abstract:
Neutrophils are important in controlling early infections with the intracellular bacterium Rhodococcus equi. Antineutrophil monoclonal antibody (RB6-8C5)-induced neutrophil deficiency during the first week after experimental infection of mice with R. equi resulted in more severe disease and significantly increased tissue concentrations of R. equi.
