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Published on: February 23, 2014
Relationship of virulence factor expression to evolved virulence in mouse-passaged Cryptococcus neoformans lines
Erin E McClelland1, Wesley T Perrine, Wayne K Potts
1Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA. mcclella@aecom.yu.edu
Infection and Immunity
|September 24, 2005
Abstract:
Serial passage of Cryptococcus neoformans in mice increases virulence relative to the nonpassaged line. Postpassaged lines showed no difference in the expression of most known virulence factors, with the exception that the more virulent lines had smaller capsules in vitro. These data imply that other mechanisms of virulence remain to be discovered.
