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Retinoids and the eye.

E G Gross1, M A Helfgott

  • 1Department of Medicine, University of Connecticut Health Center, Farmington.

Dermatologic Clinics
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Systemic retinoids, used for skin disorders and cancer chemoprevention, can cause eye side effects. These include blepharoconjunctivitis, pseudotumor cerebri, and night blindness, which are typically dose-dependent and reversible.

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SERUM SODIUM, POTASSIUM AND CHLORIDE AFTER SUPRARENALECTOMY IN CATS WITH DIABETES INSIPIDUS.

The Journal of experimental medicine·2009

Area of Science:

  • Ophthalmology
  • Dermatology
  • Pharmacology

Background:

  • Systemic retinoids are increasingly prescribed for dermatological conditions, including keratinization disorders.
  • Their potential in cancer chemoprevention suggests future widespread use.
  • Both natural and synthetic retinoids can impact ocular structures and visual metabolism.

Purpose of the Study:

  • To review the ocular side effects associated with systemic retinoid therapy.
  • To evaluate the incidence and nature of these adverse effects, particularly with isotretinoin and fenretinide.
  • To inform clinical management and future drug development.

Main Methods:

  • Literature review of studies on systemic retinoid use and ocular side effects.
  • Analysis of reported cases of blepharoconjunctivitis, pseudotumor cerebri, and night blindness.

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  • Comparison of side effect profiles across different synthetic retinoids.

    • Main Results:

    • Common ocular side effects include blepharoconjunctivitis (prominent with isotretinoin), pseudotumor cerebri, and night blindness (reported with isotretinoin and fenretinide).
    • Increased use of isotretinoin may contribute more to observed side effect incidence than individual retinoid metabolism.
    • Ocular manifestations appear to be dose-dependent and reversible.

    Conclusions:

    • Systemic retinoids, while beneficial, necessitate careful monitoring for ocular side effects.
    • Clinicians can manage these adverse events by adjusting dosage, as they are generally reversible.
    • Further evaluation of ocular safety is crucial for developing new synthetic retinoids.