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Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source.
Michael A Choma1, Kevin Hsu, Joseph A Izatt
1Duke University, Department of Biomedical Engineering, 136 Hudson Hall, Durham, North Carolina 27708, USA. mac32@duke.edu
Journal of Biomedical Optics
|September 24, 2005
Summary
A new 1300-nm swept laser source enhances spectral domain optical coherence tomography (OCT) imaging. This technology enables high-quality in vivo imaging of human cornea and skin, advancing OCT applications.
Area of Science:
- Biomedical Optics
- Optical Engineering
- Medical Imaging
Background:
- Spectral domain optical coherence tomography (OCT) sensitivity has advanced significantly.
- New OCT technologies include tunable swept laser sources and novel interferometer topologies.
Purpose of the Study:
- To demonstrate a turnkey 1300-nm swept laser source for OCT.
- To present a differential swept source OCT system for in vivo imaging.
- To analyze the impact of analog-to-digital converter aliasing on OCT image quality.
Main Methods:
- A fiber ring cavity with a semiconductor optical amplifier gain medium was used for the swept laser source.
- Intracavity mode selection was achieved using an in-fiber tunable fiber Fabry-Perot filter.
- A novel optoelectronic technique for even k-space sampling of the OCT signal was developed.
Main Results:
- A functional 1300-nm swept laser source was successfully demonstrated.
- High-quality in vivo images of human cornea and skin were acquired using the differential swept source OCT system.
- The effects of analog-to-digital converter aliasing on OCT image quality were investigated.
Conclusions:
- The developed swept laser source and OCT system are suitable for high-resolution in vivo imaging.
- The novel k-space sampling technique improves OCT signal processing.
- Understanding aliasing effects is crucial for optimizing OCT image quality.