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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Small molecule p38 inhibitors: novel structural features and advances from 2002-2005

John Hynes1, Katerina Leftheri

  • 1Department of Discovery Chemistry, Pharmaceutical Research Institute, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA.

Current Topics in Medicinal Chemistry
|September 24, 2005
PubMed
Summary

Researchers are developing small molecule inhibitors targeting p38 mitogen-activated protein kinase (MAPK) for inflammatory diseases. Recent advances in structural biology and medicinal chemistry have accelerated the discovery of potent and selective p38 MAPK inhibitors.

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