Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mast cells at mucosal frontiers.

H Vliagoftis1, A D Befus

  • 1Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada, T6G 2S2.

Current Molecular Medicine
|September 24, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adult Asthma Diagnosis: Physician Reported Challenges in Alberta-Based Primary Care Practices.

SAGE open nursing·2021
Same author

Structural and posttranslational analysis of human calcium-binding protein, spermatid-associated 1.

Journal of cellular biochemistry·2020
Same author

Proteinase-activated receptor-2 blockade inhibits changes seen in a chronic murine asthma model.

Allergy·2017
Same author

A case series evaluating the serological response of adult asthma patients to the 23-valent pneumococcal polysaccharide vaccine.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2017
Same author

Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2017
Same author

Stability of pro- and anti-inflammatory immune biomarkers for human cohort studies.

Journal of translational medicine·2017
Same journal

Corrigendum to: Sortilin as a Culprit in the Atherosclerosis Plaque Progression: Evidence from Clinical and Experimental Studies.

Current molecular medicine·2026
Same journal

Dynamic Expression of Fibroblast Activation Protein (FAP) During Chronic Pancreatitis (CP) Progression in Mice and Evaluation of FAP-targeted Tracers for Early CP Diagnosis.

Current molecular medicine·2026
Same journal

Causal Relationship Between 91 Inflammatory Factors and Gastritis: A Two-Sample Bidirectional Mendelian Randomization Study.

Current molecular medicine·2026
Same journal

Therapeutic Potential of Pistacia Atlantica Gum in Aspirin-Induced Peptic Ulcers: A Dose-Dependent Approach to Mucosal Protection and Hepatorenal Safety.

Current molecular medicine·2026
Same journal

Identification and Characterization of MicroRNAs Associated with Borax-mediated Anti-tumor Activity through High-throughput Technology.

Current molecular medicine·2026
Same journal

Broad-Spectrum Vaccines: Challenges and Opportunities (A Systematic Review).

Current molecular medicine·2026
See all related articles

Mast cells (MC) are crucial immune cells involved in allergies. Emerging research highlights their broader roles in innate and adaptive immunity, particularly in mucosal inflammation like asthma and gastrointestinal conditions.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mast cells (MC) are key players in IgE-mediated allergic inflammation.
  • Recent research reveals MC involvement in diverse physiological and pathological processes.
  • Studies now explore MC roles beyond allergic reactions, including innate and adaptive immunity.

Purpose of the Study:

  • To review the multifaceted roles of mast cells.
  • To emphasize MC involvement in inflammatory reactions at mucosal surfaces.
  • To highlight MC contributions to asthma and gastrointestinal inflammatory conditions.

Main Methods:

  • Literature review of recent advances in mast cell research.
  • Analysis of mast cell activation pathways and mediator production.
  • Focus on mast cell functions in mucosal immunity.

Related Experiment Videos

Main Results:

  • Mast cells possess diverse surface receptors for activation by various stimuli.
  • Activated mast cells release numerous pro-inflammatory mediators.
  • Mast cells significantly contribute to inflammatory conditions in organs, especially mucosal surfaces.

Conclusions:

  • Mast cells are critical immune cells with roles extending beyond allergies.
  • Their involvement in mucosal inflammation, including asthma and GI conditions, is significant.
  • Further research into mast cell functions is warranted for understanding and treating inflammatory diseases.