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Related Experiment Videos

Hormonal contraception in men.

Melanie Walton1, Richard A Anderson

  • 1Contraceptive Development Network and MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, UK.

Current Drug Targets. Immune, Endocrine and Metabolic Disorders
|September 24, 2005
PubMed
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New hormonal contraceptives for men are advancing rapidly, aiming to induce azoospermia (no sperm) through gonadotrophin suppression. This research offers a promising alternative to existing male birth control methods.

Area of Science:

  • Reproductive endocrinology and male contraception research.

Background:

  • Historical focus on female hormonal contraception, with limited male options (condoms, vasectomy) for decades.
  • Growing interest in male involvement in family planning and partner trust in male-controlled contraception.
  • Recent acceleration in male hormonal contraceptive research driven by public sector progress and pharmaceutical industry investment.

Purpose of the Study:

  • To review the progress and potential of hormonal male contraception.
  • To highlight the hormonal approach as the most advanced method currently in clinical research.
  • To discuss the underlying mechanism and challenges in developing effective hormonal male contraceptives.

Main Methods:

  • Hormonal regulation of spermatogenesis via pituitary gonadotrophin suppression.
  • Achieving azoospermia (absence of sperm) as the primary contraceptive endpoint.

Related Experiment Videos

  • Investigating various steroid formulations and delivery systems (oral, buccal, transdermal, implants) and synthetic androgens.

    • Main Results:

    • Current hormonal approaches are nearing the goal of inducing azoospermia in most men.
    • Suppression of gonadotrophins also reduces testicular testosterone production, necessitating androgen 'add-back' therapy.
    • Diverse delivery methods and steroid types are under exploration, each with unique pros and cons.

    Conclusions:

    • Hormonal male contraception is a viable and advancing field, moving closer to clinical application.
    • Androgen add-back therapy is crucial for maintaining health and efficacy.
    • Ongoing research into different steroids and delivery systems aims to optimize safety and user acceptance.