Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HTS quality control and data analysis: a process to maximize information from a high-throughput screen.

Ramesh Padmanabha1, Lynda Cook, James Gill

  • 1Lead Discovery and Profiling, Bristol-Myers Squibb Pharmaceutical Institute, Wallingford, CT 06492, USA. Ramesh.Padmanabha@bms.com

Combinatorial Chemistry & High Throughput Screening
|September 24, 2005
PubMed
Summary

Improvements in high-throughput screening (HTS) automation and informatics enhance quality control. This enables robust data mining of primary screening data, reducing drug discovery cycle times.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Value of Social Determinants of Health Needs Assessments in Primary Care.

Delaware journal of public health·2026
Same author

Career choice and interdisciplinary education in forensic pathology: a cross-sectional study.

BMC medical education·2026
Same author

National Association of Medical Examiners Position Paper: Postmortem Assessment of Suspected Head Trauma in Infant and Young Children.

The American journal of forensic medicine and pathology·2025
Same author

Youth fatal drug overdose and suicide: Trends in Connecticut, 2019-2021.

The American journal on addictions·2023
Same author

Discovery of pyrrolo[2,1-<i>f</i>][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.

Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents·2023
Same author

Peterson et al Response to Authors' Response.

Journal of forensic sciences·2021

Area of Science:

  • Drug discovery and development
  • Biotechnology
  • Pharmacology

Background:

  • High-throughput screening (HTS) is crucial for identifying drug candidates.
  • Historically, variability in HTS processes has limited data analysis.
  • Advancements in automation and informatics offer potential solutions.

Purpose of the Study:

  • To examine the impact of process improvements on HTS quality control.
  • To demonstrate the feasibility of data mining primary screening data.
  • To reduce cycle times in medicinal chemistry through enhanced HTS.

Main Methods:

  • Focus on quality control across all HTS stages, from compound management to hit/lead evaluation.
  • Leveraging infrastructure improvements in automation and informatics.

Related Experiment Videos

  • Implementing rigorous process and quality control measures.

    • Main Results:

    • Enhanced automation and informatics have improved HTS infrastructure.
    • Increased implementation of process and quality control throughout HTS.
    • Reduced variability in HTS processes leading to higher quality data.

    Conclusions:

    • Improving HTS quality control is essential for reliable primary screening data analysis.
    • Data mining of HTS data is feasible with enhanced quality control.
    • Optimized HTS processes can significantly shorten medicinal chemistry timelines.