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Multifocal chorioretinal lesions in Borzoi dogs
Eric S Storey1, Bruce H Grahn, Jane Alcorn
1Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine. storeye@vetmed.lsu.edu
Veterinary Ophthalmology
|September 24, 2005
Summary
Borzoi chorioretinopathy is an acquired condition in dogs, not inherited by simple genetic modes. Lesions appear as focal retinal degeneration and do not progress over time.
Area of Science:
- Veterinary Ophthalmology
- Canine Genetics
- Retinal Diseases
Background:
- Borzoi chorioretinopathy is a condition affecting Borzoi dogs.
- Its prevalence, characteristics, and etiology require further investigation.
Purpose of the Study:
- To determine the prevalence of Borzoi chorioretinopathy in western Canada.
- To characterize lesions using fluorescein angiography.
- To assess lesion progression and association with progressive retinal atrophy.
- To investigate the etiology of the condition.
Main Methods:
- Serial ophthalmic examinations, fundus photography, and electroretinography were performed.
- Fluorescein angiography was used to characterize lesions.
- Pedigree analysis and test breeding were conducted to assess heritability.
Main Results:
- 12 out of 103 Borzoi dogs examined showed focal retinal degeneration and RPE pigmentation.
- Lesions were non-progressive over a 5-year observation period.
- Electroretinography indicated normal retinal function in affected dogs.
- Fluorescein angiography revealed intact blood-ocular barriers and focal RPE hypertrophy.
Conclusions:
- Borzoi chorioretinopathy is an acquired condition, not inherited in simple autosomal dominant or sex-linked patterns.
- The condition initially presents as focal retinal edema and loss of choriocapillaris.
- Progressive retinal atrophy was excluded as a cause.