Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunomodulation by filarial nematodes.

A Hoerauf1, J Satoguina, M Saeftel

  • 1Institute for Medical Parasitology, University Clinic Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany. hoerauf@parasit.meb.uni-bonn.de

Parasite Immunology
|September 24, 2005
PubMed
Summary

Filarial nematodes evade host immunity by inducing regulatory T cells and macrophages to suppress immune responses. This immune modulation impacts vaccination, allergy, and co-infections, necessitating careful consideration in control programs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Paucisymptomatic opisthorchiasis in a non-endemic country: a neglected differential diagnosis?

Infection·2026
Same author

MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement.

Acta neuropathologica·2019
Same author

A prospective study on the effect of time-shifted telephone reporting of blood culture microscopy.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2019
Same author

Transcriptome-wide analysis of filarial extract-primed human monocytes reveal changes in LPS-induced PTX3 expression levels.

Scientific reports·2019
Same author

Schistosoma mansoni PCR<sup>+</sup> -infected individuals in the Sudan present elevated systemic levels of chemokines when compared to uninfected and egg<sup>+</sup> cohorts.

Clinical and experimental immunology·2019
Same author

Staphylococcus aureus versus Staphylococcus epidermidis in periprosthetic joint infection-Outcome analysis of methicillin-resistant versus methicillin-susceptible strains.

Diagnostic microbiology and infectious disease·2018

Area of Science:

  • Immunology
  • Parasitology
  • Helminthology

Background:

  • Filarial nematodes employ sophisticated strategies to evade and suppress host immune responses for chronic infection.
  • Regulatory T cells (Tregs) and alternatively activated macrophages play crucial roles in immune suppression during filariasis.
  • Understanding these down-regulatory mechanisms is vital for both basic immunology and disease management.

Purpose of the Study:

  • To elucidate the immune evasion strategies utilized by filarial nematodes.
  • To detail the roles of regulatory T cells, macrophages, and dendritic cells in filarial immune modulation.
  • To assess the broader implications of filarial-induced immune suppression on host health and interventions.

Main Methods:

  • Examination of immune responses in human and murine filariasis models.

Related Experiment Videos

  • Investigation of the induction of regulatory T cells and alternatively activated macrophages by filarial nematodes.
  • Analysis of dendritic cell function upon interaction with infective larvae.
  • Assessment of host genetic factors influencing immune response to filarial infection.

    • Main Results:

    • Filarial nematodes induce Tregs and alternatively activated macrophages that suppress Th1 and Th2 immune responses.
    • Tregs promote IgG4 secretion from B cells, contributing to immune modulation.
    • Dendritic cells are down-regulated upon initial exposure to infective L3 larvae.
    • Host genetic variations affect the response to immune down-regulation, influencing parasite load and pathology.

    Conclusions:

    • Filarial nematode infections induce a complex immune suppression network involving Tregs, macrophages, and B cells.
    • This immune suppression can extend to unrelated antigens, affecting vaccination efficacy and allergy.
    • Genetic factors influence susceptibility and disease manifestation in filariasis.
    • Understanding these mechanisms is critical for managing filariasis control programs and mitigating adverse effects on public health, including co-infections like malaria.