Pathways to improving skin regeneration
Christelle Adolphe1, Brandon Wainwright
1Institute for Molecular Bioscience, Queensland Bioscience Precinct, Building 80, Services Road, University of Queensland, St Lucia, 4072, Brisbane, Queensland, Australia. c.adolphe@imb.uq.edu.au
Abstract:
A significant proportion of the human population suffers from some form of skin disorder, whether it be from burn injury or inherited skin anomalies. The ideal treatment for skin disorders would be to regrow skin tissue from stem cells residing in the individual patient's skin. Locating these adult stem cells and elucidating the molecules involved in orchestrating the production of new skin cells are important steps in devising more-efficient methods of skin production and wound healing via the ex vivo expansion of patient keratinocytes in culture. This review focuses on the structure of the skin, the identification of skin stem cells, and the role of Notch, Wnt and Hedgehog signalling cascades in regulating the fate of epidermal stem cells.
Related Concept Videos
Renewal of Skin Epidermal Stem Cells
Clinical Applications of Epidermal Stem Cells
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Healing I: Introduction
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

