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Updated: May 11, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Finding the fittest fold: using the evolutionary record to design new proteins

Robert G Smock1, Lila M Gierasch

  • 1Department of Biochemistry & Molecular Biology, University of Massachusetts Amherst, 01003, USA.

Cell
|September 24, 2005
PubMed
Summary

Researchers successfully designed artificial WW domains, a key goal in protein engineering. Their novel statistical coupling analysis method leverages evolutionary data to predict amino acid patterns for protein design.

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