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Penetration of roxithromycin into gingival tissue
F Jehl1, R Kolbe, A Scheimberg
1Department of Pharmacokinetics, Institute of Bacteriology, Strasbourg, Paris, France.
Diagnostic Microbiology and Infectious Disease
|May 1, 1992
Summary
Roxithromycin effectively penetrates gingival tissue, achieving concentrations above the minimum inhibitory concentration for oral pathogens. This macrolide antibiotic demonstrates promising efficacy for treating oral infections.
Area of Science:
- Pharmacology
- Microbiology
- Oral Medicine
Background:
- Roxithromycin is a macrolide antibiotic with an antibacterial spectrum comparable to erythromycin.
- It exhibits rapid absorption, high serum levels, and a long half-life.
- Extensive and sustained tissue distribution has been observed in various organs.
Purpose of the Study:
- To quantify the penetration of roxithromycin into gingival tissue at steady state.
- To evaluate roxithromycin concentrations in relation to the minimum inhibitory concentration (MIC90) against oral pathogens.
Main Methods:
- 30 patients received oral roxithromycin (150 mg every 12 hr for 5 days).
- Gingival tissue and blood samples were collected at specific time points (2, 4, 6, 8, 12 hr) after the 10th dose.
- Roxithromycin concentrations in serum and tissue were determined using high-performance liquid chromatography.
Main Results:
- Peak serum concentration of roxithromycin was 6.60 ± 1.15 µg/ml at 4 hr.
- Peak gingival tissue concentration was 4.63 ± 1.84 µg/g, achieved at 8 hr.
- Tissue concentrations remained above 2 µg/g between 4 and 10 hr post-dosing, exceeding the MIC90 for most oral pathogens.
Conclusions:
- Roxithromycin demonstrates significant penetration into gingival tissue.
- Sustained therapeutic concentrations in gingival tissue support its use in treating oral infections.
- The pharmacokinetic profile of roxithromycin in oral tissues warrants further investigation for targeted therapies.