Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Delineating and understanding cerebellar neuroprotective pathways: potential implication for protecting the cortex.

Xuan Wu1, Xueying Jiang, Ann M Marini

  • 1Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA.

Annals of the New York Academy of Sciences
|September 24, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

α-linolenic acid-induced facilitation of GABAergic synaptic transmission is mediated via acid-sensing ion channel (ASIC1a) activity in the basolateral amygdala.

Experimental biology and medicine (Maywood, N.J.)·2025
Same author

Traumatic brain injury: molecular biomarkers, genetics, secondary consequences, and medical management.

Frontiers in neuroscience·2024
Same author

Mechanistic and therapeutic relationships of traumatic brain injury and γ-amino-butyric acid (GABA).

Pharmacology & therapeutics·2024
Same author

Alpha-linolenic acid enhances the facilitation of GABAergic neurotransmission in the BLA and CA1.

Experimental biology and medicine (Maywood, N.J.)·2023
Same author

A review of horses sent to slaughter for human consumption: impact of horsemeat consumption, residual banned drugs, and public health risks.

American journal of veterinary research·2023
Same author

Rehabilitation of motor function after stroke: A bibliometric analysis of global research from 2004 to 2022.

Frontiers in aging neuroscience·2022

The cerebellum protects itself from neurodegeneration via intrinsic survival pathways. Activating N-methyl-d-aspartate (NMDA) receptors shields neurons from excitotoxicity, supporting cerebellar cognitive functions.

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Neurodegenerative Diseases

Background:

  • The cerebellum exhibits remarkable resistance to neurodegenerative conditions like stroke and Alzheimer's disease, unlike the vulnerable neocortex.
  • Accumulating evidence suggests the cerebellum's role extends beyond motor control to memory and higher cognitive functions.

Purpose of the Study:

  • To investigate intrinsic survival pathways in cerebellar granule cells.
  • To explore the role of N-methyl-d-aspartate (NMDA) receptor stimulation in neuronal protection.
  • To understand how NMDA receptor modulation influences cerebellar function in cognition and memory.

Main Methods:

  • Focused on intrinsic survival pathways within cerebellar granule cells.
  • Examined the effects of low-level N-methyl-d-aspartate (NMDA) receptor stimulation.

Related Experiment Videos

  • Investigated a brain-derived neurotrophic factor (BDNF)-mediated pathway.

    • Main Results:

    • Identified intrinsic survival pathways in cerebellar granule cells regulated by NMDA receptor stimulation.
    • NMDA receptor activation demonstrated neuroprotective effects against glutamate-mediated excitotoxicity.
    • A BDNF-mediated pathway was implicated in NMDA receptor-induced neuronal survival.

    Conclusions:

    • The cerebellum possesses intrinsic mechanisms for self-protection against neurodegeneration.
    • NMDA receptor modulation, via a BDNF pathway, plays a key role in cerebellar neuronal survival.
    • These findings support the cerebellum's critical involvement in learning, memory, and cognitive processing.