Related Experiment Video

Updated: Aug 15, 2026

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

Effects of tomato paste extracts on cell proliferation, cell-cycle arrest and apoptosis in LNCaP human prostate

Eun-Sun Hwang1, Phyllis E Bowen

  • 1Department of Human Nutrition, University of Illinois, Chicago, IL 61801, USA.

Biofactors (Oxford, England)
|September 24, 2005
PubMed

Insights

Tomato hexane extract significantly inhibits prostate cancer cell growth and alters cell cycle progression. This suggests tomatoes may possess chemopreventive properties against prostate cancer.

Area of Science:

  • Oncology
  • Nutritional Science
  • Molecular Biology

Background:

  • Tomato consumption is linked to reduced prostate cancer risk.
  • Understanding the bioactive components of tomatoes is crucial for cancer prevention research.

Purpose of the Study:

  • To investigate the effects of tomato extracts on LNCaP human prostate cancer cells.
  • To identify bioactive tomato fractions that can modulate cancer biomarkers.

Main Methods:

  • Preparation of whole tomato paste, water extract, and hexane extract.
  • Incubation of LNCaP cells with extracts for 6, 24, and 48 hours.
  • Measurement of cell proliferation, cell cycle progression, and apoptosis.

Main Results:

  • Tomato paste hexane extract inhibited cell proliferation by 33% after 48 hours.
  • Hexane extract at 5 microM lycopene increased G2/M-phase and decreased S-phase.
  • Apoptosis was observed with the hexane extract at later treatment stages.

Conclusions:

  • Tomato hexane extract demonstrates significant anti-proliferative and cell cycle-modulating effects on prostate cancer cells.
  • Tomatoes, particularly their hexane-extractable compounds, show potential as chemopreventive or chemotherapeutic agents.

More Related Videos

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput12:22

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput

Published on: September 22, 2019

An Orthotopic Murine Model of Human Prostate Cancer Metastasis06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...