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Updated: Dec 31, 2025
Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) -- structural investigations on two different
Anne Saupe1, Sylvia A Wissing, Andreas Lenk
1Department of Pharmaceutical Technology, Biotechnology & Quality Management, Kelchstr. 31, 12169 Berlin, Germany.
Abstract:
Two different types of colloidal lipid particles are presented and compared as innovative carrier systems. Size distribution and storage stability of formulations produced by hot high pressure homogenisation in lab and medium scale production were investigated by laser diffractometry (LD) and photon correlation spectroscopy (PCS). Nanoparticles were characterised by their melting and recrystallisation behaviour recorded by differential scanning calorimetry (DSC). Electron microscope investigations were also carried out showing the particulate character of these carriers. Reasons for observed differences in loading capacity are discussed and possibilities for dermal application are described.
