Effect of estrogen on hypoglycemia-induced neurological impairment in ovariectomized rats

The risk of hypoglycemia and the resulting functional derangement of the brain are one of the major complications with stringently controlled diabetes mellitus. Ovarian steroid hormones, particularly estradiol, play a modulatory role in the ability of the female brain to utilize glucose. In the present study, the effects of estrogen on hypoglycemia-induced neurological impairment were done in ovariectomized rats. Animals received either vehicle or estradiol benzoate treatment. Hypoglycemia (Blood glucose levels <50 mg/dl) was induced in all the rats by insulin (2 U/kg, IP). Neurological functions were assessed using an 18 point scale at different time intervals of hypoglycemia. Estradiol benzoate (100 microg/kg IP) significantly (p<0.05) deteriorated the neurological functions in ovariectomized rats during hypoglycemia. The present study thus reveals that estradiol benzoate is responsible for further aggravation of neurological impairment induced by insulin hypoglycemia in female rats.