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Related Experiment Videos

Effect of herbal polyphenols on atherogenic transcriptome.

Deepak Kaul1, Akshay R Shukla, Kavleen Sikand

  • 1Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. dkaul_24@hotmail.com

Molecular and Cellular Biochemistry
|September 24, 2005
PubMed
Summary

Polyphenols from Indian medicinal herbs like Tulsi can inhibit genes linked to atherosclerosis. A specific Tulsi extract shows significant potential for antiatherogenic effects, supporting traditional medicine.

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Area of Science:

  • Phytochemistry
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Ancient Indian medicine suggests herbs possess antiatherogenic properties.
  • Atherogenesis involves complex gene interactions controlling lipid metabolism and arterial wall activity.
  • Key genes in atherogenesis include LDLR, LXRalpha, PPARs, CD-36, and c-myc.

Purpose of the Study:

  • To investigate the effect of medicinal herb polyphenols on the transcription of atherogenesis-related genes.
  • To explore the antiatherogenic potential of polyphenols from Green tea, Neem, and Tulsi.

Main Methods:

  • Extraction and purification of polyphenols from Green tea, Neem, and Tulsi.
  • Culture of normal human mononuclear cells with polyphenol extracts.
  • Measurement of gene transcriptional expression using RT-PCR and SCION IMAGE analysis.

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Main Results:

  • Polyphenolic extracts demonstrated an ability to inhibit the transcriptional expression of atherogenic genes.
  • HPLC-purified polyphenolic fraction IV from Tulsi exhibited a notable inhibitory effect.

Conclusions:

  • Medicinal herb polyphenols can modulate gene transcription involved in the atherogenic process.
  • Tulsi's HPLC-purified polyphenolic fraction IV presents a promising antiatherogenic therapeutic candidate.