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Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains

Daniel L Koller1, Imranul Alam, Qiwei Sun

  • 1Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, IB 130, Indianapolis, Indiana, 46202, USA. dkoller@iupui.edu

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|September 24, 2005
PubMed

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Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...