Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alzheimer's disease and stroke.

K Dineley1, L Denner

  • 1Division of Neuroscience, Baylor College of Medicine, USA.

Idrugs : the Investigational Drugs Journal
|September 24, 2005
PubMed
Summary

This study examines Alzheimer's disease (AD) and stroke, focusing on neuronal cell death. It investigates apoptosis as a common mechanism underlying these prevalent neurological conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Involvement of RB kinases and phosphatases in life and death decisions.

Oncology reports·2011
Same author

Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors.

Neuroscience·2010
Same author

Oct-4A isoform is expressed in human cord blood-derived CD133 stem cells and differentiated progeny.

Cell proliferation·2009
Same author

Directed engineering of umbilical cord blood stem cells to produce C-peptide and insulin.

Cell proliferation·2007
Same author

Production of stem cells with embryonic characteristics from human umbilical cord blood.

Cell proliferation·2005
Same author

Society for Neuroscience--30th Annual Meeting. Alzheimer's disease: Therapeutics, targets and screens.

IDrugs : the investigational drugs journal·2005

Area of Science:

  • Neurology
  • Cell Biology
  • Pathology

Background:

  • Alzheimer's disease (AD) and stroke are leading causes of neurological disability.
  • Neuronal cell death is a critical pathological feature in both AD and stroke.
  • Apoptosis, or programmed cell death, is a significant pathway involved in neurodegeneration.

Purpose of the Study:

  • To review the commonalities between Alzheimer's disease and stroke.
  • To highlight the role of neuronal cell death in these conditions.
  • To explore apoptosis as a central mechanism in the pathogenesis of AD and stroke.

Main Methods:

  • Literature review of studies on Alzheimer's disease.
  • Literature review of studies on stroke.
  • Analysis of research on apoptosis in neurological diseases.

Main Results:

  • Alzheimer's disease and stroke share neuronal cell death as a common pathological outcome.
  • Apoptosis is a frequently implicated mechanism contributing to neuron loss in both diseases.
  • Understanding apoptotic pathways may offer therapeutic targets for both AD and stroke.

Conclusions:

  • Neuronal apoptosis is a key shared mechanism in Alzheimer's disease and stroke.
  • Targeting apoptosis could be a potential therapeutic strategy for managing these neurological disorders.
  • Further research into the specific apoptotic pathways is warranted for both conditions.

Related Experiment Videos