Related Experiment Video
Updated: Aug 15, 2026
An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma
Published on: November 15, 2024
Repair of pig dura in vivo using temperature controlled CO(2) laser soldering
Boaz Forer1, Tamar Vasilyev, Tamar Brosh
1Department of Otolaryngology, Head and Neck Surgery, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.
Background And Objectives:
The purpose of this study was to demonstrate that laser soldering might be successfully used for closing holes or cuts in the dura layer, which encapsulates the brain.
Study Design/Materials And Methods:
A temperature controlled fiberoptic CO(2) laser system and albumin solder were used for spot soldering of fascia patches to holes in the dura of farm pigs, in vitro and in vivo.
Results:
The mean burst pressure of the soldered patches in the in vitro experiments was 190 +/- 88 mm Hg-significantly higher than typical maximum CSF pressure of 15 mm Hg. In the in vivo experiments the pigs showed no postoperative complications. Histopathological studies exhibited an accepted level of inflammatory reaction and showed no thermal damage to the underlying brain tissue.
Conclusions:
It has been clearly demonstrated that temperature controlled laser soldering is a very useful technique for the repair of the dura. It provides significant advantages over standard closure techniques: it is easy to apply, the bond is strong and watertight and the procedure is likely to be much faster than suturing. This research work will lead to clinical trials.
