Lehualides A-D, metabolites from a Hawaiian sponge of the genus Plakortis
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Published on: February 11, 2010
Noriko Sata1, Hazel Abinsay, Wesley Y Yoshida
1Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
Abstract:
A collection of an undescribed marine sponge of the genus Plakortis yielded four new "polyketide-derived" metabolites, lehualides A-D (1-4). The structures of compounds 1-4 were elucidated by interpretation of spectral data. Compound 2 demonstrated cytotoxicity against an ovarian cancer cell line, while compound 4 was active against both ovarian cancer and leukemia cell lines.
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