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Homocysteine level in patients with established transmural myocardial infarction
Muhammad Ishaq Salahuddin1, S I Ahmed
1Department of Biochemistry, Hamdard College of Medicine and Dentistry, Hamdard University, Karachi, Pakistan. drsalahuddin2002@yahoo.com
Insights
Elevated serum total homocysteine and abnormal lipid profiles, including high LDL-C and low HDL-C, are linked to increased risk of myocardial infarction in the local population. These findings highlight potential biomarkers for coronary artery disease.
Area of Science:
- Cardiology
- Clinical Biochemistry
- Epidemiology
Background:
- Coronary artery disease (CAD) poses a significant health burden globally.
- Serum total homocysteine is increasingly recognized as a potential risk factor for cardiovascular diseases.
- Understanding local population-specific risk factors is crucial for targeted prevention strategies.
Purpose of the Study:
- To investigate serum total homocysteine levels in patients with transmural myocardial infarction compared to healthy controls.
- To assess the association between homocysteine, lipid parameters, and myocardial infarction in the local demographic.
Main Methods:
- A case-control study involving 63 patients with anterior wall transmural myocardial infarction and 21 healthy controls.
- Serum total homocysteine measured by fluorescence polarization immunoassay (FPIA).
- Lipid parameters and plasma glucose analyzed using enzymatic colorimetric methods.
Main Results:
- Significantly higher mean serum total homocysteine and low-density lipoprotein cholesterol (LDL-C) levels were observed in myocardial infarction patients.
- Mean high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in the patient group.
- While serum glucose, total cholesterol, and triacylglycerol were higher in patients, the differences were not statistically significant.
Conclusions:
- Elevated serum total homocysteine, high LDL-C, and low HDL-C are significantly associated with an increased risk of coronary artery disease in the studied population.
- These biochemical markers may serve as important indicators for assessing CAD risk.
- Further research is warranted to explore the clinical implications and management strategies related to these findings.
Objective:
To evaluate the levels of serum total homocysteine in patients suffering from established transmural myocardial infarction and normal healthy subjects of local population.
Design:
A case control study.
Place And Duration Of Study:
The present study was carried out at Dr. Hafiz Muhammad Ilyas (HMI) Institute of Pharmacology and Herbal Sciences in collaboration with National Institute of Cardiovascular Diseases, Karachi, from June 2001 to December 2001.
Patients And Methods:
Eighty-four persons were included in a case control study. Sixty-three patients were cases suffering from transmural myocardial infarction of anterior wall and 21 normal healthy subjects were controls having no history of IHD ever before. Fasting venous serum was analyzed for total homocysteine using fluorescence polarization immunoassay (FPIA) while lipid parameters and plasma glucose were estimated by enzymatic colorimetric method.
Results:
Mean serum total homocysteine and low density lipoprotein cholesterol (LDL-C) levels [19.43+/-2.46 umol/L, 124.97+/-45.31 mg/dl respectively] were found to be significantly higher in cases as compared to controls. The mean serum High density lipoprotein cholesterol (HDL-C) [27.57+/-15.31 mg/dl] was found to be significantly lower as compared to control. Mean serum glucose, total cholesterol and serum triacylglycerol [84.32+/-2.46 mg/dl, 174.35+/-27.08 mg/dl and 148.49+/-43.12 mg/dl respectively] were higher in patients as compared to control but difference was insignificant statistically.
Conclusion:
Significantly high levels of total homocysteine along with high levels of LDL-C and low levels of HDL-C appear to be the factors responsible for the increase risk of coronary artery disease in our local population.
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