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Updated: Aug 15, 2026

Real-Time Quantification of the Effects of IS200/IS605 Family-Associated TnpB on Transposon Activity
Published on: January 20, 2023
The transpososome: control of transposition at the level of catalysis
E Gueguen1, P Rousseau, G Duval-Valentin
1Laboratoire de Microbiologie et Génétique Moléculaires, CNRS UMR5100, 118 Route de Narbonne, 31062 Toulouse Cedex, France.
Abstract:
Studies of several transposable genetic elements have pinpointed the importance of the transpososome, a nucleoprotein complex involving the transposon ends and a transposon-encoded enzyme--the transposase--as a key in regulating transposition. Transpososomes provide a precise architecture within which the chemical reactions involved in transposon displacement occur. Data are accumulating that suggest they are dynamic and undergo staged conformational changes to accommodate different steps in the transposition pathway. This has been underpinned by recent results obtained particularly with Tn5, Tn10 and bacteriophage Mu.
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