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Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner
Marie K Hoeger Bement1, Kathleen A Sluka
1Physical Therapy Department, Integrative Neuroscience Research Center, College of Health Sciences, Marquette University, Milwaukee, WI 53201, USA. mariehoeger.bement@marquette.edu
Objective:
To determine the effects of low-intensity exercise on chronic muscle pain and potential activation of the endogenous opioid system.
Design:
Randomized placebo-controlled trial.
Setting:
Animal laboratory.
Animals:
Sixty-three male Sprague-Dawley rats.
Interventions:
Rats performed a low-intensity exercise protocol for 5 consecutive days after the induction of chronic muscle pain. In a separate experiment, naloxone or saline was administered systemically before 5 low-intensity exercise sessions.
Main Outcome Measure:
Mechanical hyperalgesia was measured using von Frey filaments to determine the mechanical withdrawal threshold.
Results:
Low-intensity exercise increased mechanical withdrawal threshold in the chronic muscle pain model. Naloxone attenuated the antihyperalgesic effects of low-intensity exercise.
Conclusions:
Low-intensity exercise reversed mechanical hyperalgesia in the chronic muscle pain model through activation of the endogenous opioid system.
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