Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxygen availability and motor unit activity in humans.

T Moritani1, W M Sherman, M Shibata

  • 1Laboratory of Applied Physiology, College of Liberal Arts and Sciences, Kyoto University, Japan.

European Journal of Applied Physiology and Occupational Physiology
|January 1, 1992
PubMed
Summary

Restricting blood flow during hand grip exercise increases motor unit activity and lactate levels, suggesting metabolic state influences muscle recruitment. This impacts understanding of muscle fatigue and control during physical exertion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined dorsal forearm and lateral arm flap.

Plastic and reconstructive surgery·1995
Same author

Prostacyclin receptor activation and pial arteriolar dilation after endothelial injury in piglets.

Stroke·1995
Same author

Reduced muscle uptake of oxygen during exercise in patients with systemic lupus erythematosus.

The Journal of rheumatology·1995
Same author

[Retrovirus and autoimmune diseases].

Ryumachi. [Rheumatism]·1995
Same author

Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids.

Pediatric research·1995
Same author

Different pial arteriolar responses to acetylcholine in the newborn and juvenile pig.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·1994

Area of Science:

  • Exercise Physiology
  • Muscle Physiology
  • Neuromuscular Function

Background:

  • Understanding the interplay between muscle blood supply, motor unit (MU) activity, and metabolic changes is crucial for comprehending exercise responses.
  • Intermittent isometric contractions are a common model for studying muscle fatigue and adaptation.

Purpose of the Study:

  • To investigate the relationship between blood circulation, MU activity, and lactate concentrations during hand grip exercise.
  • To determine how arterial occlusion affects electrophysiological and metabolic markers of muscle function.

Main Methods:

  • Six male subjects performed intermittent isometric hand grip contractions (2s on, 2s off) at 20% maximal voluntary contraction (MVC) for 4 minutes.
  • Simultaneous recording of intramuscular MU activity, surface electromyogram (EMG), and venous lactate concentrations.

Related Experiment Videos

  • Comparison between conditions of unhindered blood circulation and temporary arterial occlusion.

    • Main Results:

    • Unhindered circulation showed no electrophysiological signs of muscle fatigue.
    • Arterial occlusion led to significant increases in MU spike amplitude and firing frequency.
    • Surface EMG spectral parameters and venous lactate concentrations also increased significantly with occlusion.
    • Force output remained constant despite changes in MU activity and metabolism.

    Conclusions:

    • Muscle metabolic state, particularly under conditions of reduced blood supply, plays a significant role in regulating MU recruitment and firing rate.
    • Electrophysiological signs of fatigue do not necessarily correlate with force production during intermittent contractions when blood flow is compromised.
    • These findings offer insights into the neural control of muscle during exercise and the development of fatigue.