Uterine cervix carcinoma. Histological radiation response (H.R.R.)

As most Carcinoma of the Uterine Cervix (CUC) has been found at advanced stages, Radiotherapy (RT) is still the most important treatment. Unfortunately not all CUC are responsive to RT Histological Radiation Response of the CUC according to Saryadi and Osborne (1975) determines 3 grades: good--moderate--poor HRR respectively, which conforms with the Cancer cells response grading according to National Cancer Center Hospital in Japan. In 1982, B. Hadiyanto and Sutoto reported a highly significant difference in the 5 y.s.r. of CUC patients who had better RHH (N = 52). In 1989, Sutoto, Suprijono and W. Adijono also reported highly significant differences among such groups of patients, of whom part received High-dosage of Mitomycin C (N = 46). Lately, Ristiyati and Sutoto have also found that the 5 y.s.r. among 187 patients treated with Radiotherapy alone and R.R. + Mitomycin showed significantly better survival in patients with better HRR. These studies showed that HRR is one of the most important points in CUC Radiotherapy. It has potential use in improving the result of RT, such as: Switching further treatment to surgery; Administering more aggressive adjuvant chemotherapy, among the worst responders.