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CYP2J2*7 single nucleotide polymorphism in a Chinese population.
Haijian Wang1, Yan Jiang, Yang Liu
1Laboratory of Systems Biology, Institutes of Biomedical Sciences, Fudan University, 138 Yixueyuan Rd., Shanghai 200032, PR China.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|September 27, 2005
Summary
The CYP2J2*7 genetic variant is rare in the Chinese population, with an allele frequency of 2.60%. This finding is important for future studies on diseases and drug metabolism influenced by cytochrome P450 2J2 (CYP2J2) gene variations.
Area of Science:
- Pharmacogenomics
- Human Genetics
- Molecular Biology
Background:
- Human cytochrome P450 2J2 (CYP2J2) is a key enzyme in arachidonic acid metabolism, implicated in cardiovascular disorders and cancers.
- CYP2J2 also influences the metabolism of certain antihistamine drugs.
- A functionally significant single nucleotide polymorphism, CYP2J2*7, exhibits notable ethnic variations in allele frequency.
Purpose of the Study:
- To characterize the frequency of the CYP2J2*7 polymorphism in the Chinese Han population.
- To compare the CYP2J2*7 allele frequency in Chinese with other ethnic groups.
Main Methods:
- Genotyping of the CYP2J2*7 polymorphism was performed using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) assays.
- A sample of 384 healthy Chinese Han subjects was analyzed.
Main Results:
- The CYP2J2*7 allele frequency in the studied Chinese population was found to be 2.60%.
- Heterozygotes for the CYP2J2*7 allele were observed in 5.21% of subjects, with no homozygotes detected.
Conclusions:
- The CYP2J2*7 variant is a relatively rare polymorphism among Chinese individuals.
- The observed allele frequency is comparable to that in Koreans but significantly lower than in African and White populations.
- These findings are valuable for designing population-based association studies concerning CYP2J2-related diseases and therapeutic responses.