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Updated: Aug 15, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Making light work of enzyme catalysis: protochlorophyllide oxidoreductase
Derren J Heyes1, C Neil Hunter
1Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK. d.j.heyes@shef.ac.uk
Abstract:
In the chlorophyll biosynthetic pathway, the enzyme protochlorophyllide oxidoreductase (POR) catalyses a key light-driven reaction that triggers a profound transformation in plant development. Because POR is activated by light, it can provide information on the way in which light energy can be harnessed to power enzyme reactions and it presents us with a unique opportunity to study catalysis at low temperatures and on ultrafast timescales that are not accessible for most analyses of enzyme function. Recent advances in our understanding of the catalytic mechanism of POR illustrate why it is an important generic model for studying enzyme catalysis and reaction dynamics.
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