Kidney transplantation from elderly donors: a prospective randomized study comparing celsior and UW solutions

Area of Science:

• Transplantation immunology
• Organ preservation solutions
• Nephrology

Background:

• Kidney transplantation is a vital treatment for end-stage renal disease.
• The use of elderly donor kidneys is increasing, necessitating optimal preservation strategies.
• Comparing preservation solutions is crucial for improving transplant outcomes.

Purpose of the Study:

• To compare the efficacy of Celsior solution versus University of Wisconsin (UW) solution for preserving kidneys from elderly donors.
• To assess the impact of these solutions on immediate and long-term kidney transplant function.

Main Methods:

• A prospective, multicenter randomized study involving 50 kidney transplants from donors over 60 years old.
• Kidneys were preserved in either Celsior (n=25) or UW solution (n=25).
• Outcomes evaluated included delayed graft function, urinary output, serum creatinine levels, and graft survival at 1 and 5 years.

Main Results:

• No significant differences were observed in warm or cold ischemia times between the Celsior and UW groups.
• Delayed graft function rates were comparable (48% for Celsior vs. 52% for UW).
• One- and 5-year graft survival rates were similar, with no statistically significant differences between the preservation solutions.

Conclusions:

• Celsior solution is equivalent to UW solution for the preservation of kidneys from elderly donors.
• These findings support the use of Celsior as a viable alternative preservation strategy.
• The study indicates that donor age does not preclude the effective use of Celsior for kidney preservation.