Amitriptyline produces analgesia in the formalin pain test
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J Acton1, J E McKenna, R Melzack
1Department of Psychology, McGill University, Montreal, Quebec, Canada.
Experimental Neurology
|July 1, 1992
Abstract:
A dose of 20 mg/kg of amitriptyline reduced pain in the second phase of the formalin test, which is an animal model of long-lasting pain in humans. Since the analgesic effect was produced by a single dose, which is insufficient to produce an antidepressant effect, these results indicate that amitriptyline has analgesic properties that are independent of its antidepressant properties.