Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Local protection for surgical implants.

Martin Lucke1

  • 1Center for Musculoskeletal Surgery, Charité-University Medicine Berlin, Germany.

Chemistry & Biology
|September 27, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Attitude of health care workers towards SARS-CoV-2 vaccination].

MMW Fortschritte der Medizin·2021
Same author

Perioperative multi-system optimization protocol in elderly hip fracture patients: a randomized-controlled trial.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2019
Same author

Influence of Absorbable Calcium Sulfate-Based Bone Substitute Materials on Human Haemostasis-In Vitro Biological Behavior of Antibiotic Loaded Implants.

Materials (Basel, Switzerland)·2018
Same author

Polyaxial locking plates in treating distal humeral fractures: a comparative randomized trial for clinical outcome.

BMC musculoskeletal disorders·2017
Same author

Malpositioned olecranon fracture tension-band wiring results in proximal radioulnar synostosis.

European journal of medical research·2015
Same author

Tumor Growth Inhibition via Occlusion of Tumor Vasculature Induced by N-Terminally PEGylated Retargeted Tissue Factor tTF-NGR.

Molecular pharmaceutics·2015

Researchers covalently attached vancomycin to titanium surfaces. This new material effectively combats Staphylococcus aureus, offering potential for preventing infections after implant surgery.

Area of Science:

  • Biomaterials Science
  • Infectious Disease Research
  • Surface Chemistry

Background:

  • Implant-associated infections pose a significant clinical challenge, often caused by bacteria like Staphylococcus aureus.
  • Current strategies for preventing surgical site infections have limitations.
  • Developing novel antimicrobial materials is crucial for improving patient outcomes.

Purpose of the Study:

  • To covalently immobilize the antibiotic vancomycin onto a titanium surface.
  • To evaluate the efficacy of vancomycin-tethered titanium against Staphylococcus aureus.
  • To explore the potential of this functionalized material in preventing implant-related infections.

Main Methods:

  • Covalent attachment of vancomycin to a functionalized titanium surface.

Related Experiment Videos

  • Antimicrobial susceptibility testing against Staphylococcus aureus.
  • Surface characterization of the modified titanium material.

    • Main Results:

    • Successful covalent attachment of vancomycin to the titanium surface was achieved.
    • The vancomycin-tethered titanium demonstrated significant antimicrobial activity against Staphylococcus aureus.
    • The functionalized material maintained its effectiveness, indicating stability.

    Conclusions:

    • Covalently attaching vancomycin to titanium creates a potent antimicrobial surface.
    • This approach shows promise as an adjunct therapy for preventing infections in orthopedic and dental implant surgeries.
    • Further research could lead to advanced biomaterials for infection control.