Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin and sleep in aging population.

S R Pandi-Perumal1, N Zisapel, V Srinivasan

  • 1Comprehensive Center for Sleep Medicine; Department of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, 1176 - 5th Avenue, 6th Floor, NY 10029, USA.

Experimental Gerontology
|September 27, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Polymorphism Cluster at the 2q12 locus May Predict Response to Piromelatine in Patients with Mild Alzheimer's Disease.

The journal of prevention of Alzheimer's disease·2022
Same author

Efficacy of vitamin D replacement therapy in restless legs syndrome: a randomized control trial.

Sleep & breathing = Schlaf & Atmung·2018
Same author

Hepatitis B Vaccination Rate in Patients with Diabetes: Assessment of Racial and Socioeconomic Disparity.

International journal of clinical endocrinology and metabolism·2017
Same author

Telemetric field studies of body temperature and activity rhythms of Acomys russatus and A. cahirinus in the Judean Desert of Israel.

Oecologia·2017
Same author

Restless legs syndrome and pregnancy: prevalence, possible pathophysiological mechanisms and treatment.

Acta neurologica Scandinavica·2015
Same author

Daily activity patterns of 2316 men and women from five countries differing in socioeconomic development.

Chronobiology international·2015
Same journal

Astragalus membranaceus and Salvia miltiorrhiza injections confer cardioprotection via SERCA/SIRT1-mediated Ca<sup>2+</sup> regulation.

Experimental gerontology·2026
Same journal

Ayurvedic nutraceutical, Chyawanprash, enhances longevity and stress resilience via mitochondrial and muscular health in C. elegans model of ageing.

Experimental gerontology·2026
Same journal

Activation of Sirt3 reprograms mitochondrial function to regenerate intervertebral disc degeneration.

Experimental gerontology·2026
Same journal

Sit-to-stand power shows greater magnitude associations with radial bone strength compared to handgrip strength in adults aged 60-95 years: A cross-sectional study.

Experimental gerontology·2026
Same journal

Impact of simultaneous motor-cognitive training on motor capacities in older adults: A quasi-randomized parallel controlled trial.

Experimental gerontology·2026
Same journal

Triglyceride-glucose-related metabolic indices, phenotypic aging, and incident pulmonary embolism.

Experimental gerontology·2026
See all related articles

Melatonin, a neurohormone, regulates sleep and declines with age. Exogenous melatonin effectively improves sleep in elderly individuals and Alzheimer's patients with diminished natural production.

Area of Science:

  • Neuroscience
  • Chronobiology
  • Sleep Medicine

Background:

  • The neurohormone melatonin, produced by the pineal gland, is closely linked to the light-dark cycle and plays a role in regulating sleep.
  • Aging is associated with reduced sleep quality and continuity, often accompanied by decreased melatonin production.
  • Alzheimer's disease (AD) patients frequently exhibit diminished nocturnal melatonin secretion and disrupted sleep-wake rhythms.

Purpose of the Study:

  • To investigate the role of melatonin in the physiological regulation of sleep.
  • To evaluate the effectiveness of exogenous melatonin in different age groups and specific patient populations with sleep disturbances.
  • To understand the conditions under which exogenous melatonin is most beneficial for sleep.

Main Methods:

Related Experiment Videos

  • Review of existing studies on melatonin secretion, sleep patterns, and the effects of exogenous melatonin.
  • Analysis of clinical trial data involving elderly insomniacs and Alzheimer's disease patients with sleep disturbances.
  • Consideration of the efficacy of melatonin receptor agonists like ramelteon.

    • Main Results:

    • While a general survey showed limited effects of exogenous melatonin on sleep across all age groups, clinical trials indicate significant benefits for elderly insomniacs and AD patients.
    • Exogenous melatonin appears most effective in individuals with reduced endogenous melatonin production.
    • A melatonin analog, ramelteon, has been developed as a hypnotic agent with no reported abuse or dependence issues.

    Conclusions:

    • Exogenous melatonin can be an effective therapeutic option for sleep disturbances, particularly in populations with age-related or disease-related declines in endogenous melatonin.
    • The efficacy of melatonin for sleep promotion is context-dependent, highlighting the importance of endogenous melatonin levels.
    • Targeting melatonin pathways offers a promising avenue for developing novel sleep aids.