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Updated: Aug 15, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
Published on: April 25, 2014
Treatment of multiple drug-resistant tuberculosis (MDR-TB) in Iran
Seyed Mehdi Mirsaeidi1, Payam Tabarsi, Kaveh Khoshnood
1Department of Tuberculosis and Respiratory Infections, Iranian National Research Institute of Tuberculosis and Lung Diseases, Tehran 19556, Iran. mmirsaeidi@nritld.ac.ir
Setting:
Masih Daneshvari Hospital, Tehran, Iran, 2000-2002.
Objective:
To evaluate the effectiveness of multiple drug-resistant tuberculosis (MDR-TB) treatment for the first time in Iran.
Design:
All cases of MDR-TB with complete follow-up data were recruited and results of their treatments were evaluated.
Results:
MDR-TB treatment was initiated with 5.23 drugs, on average. Isoniazid, amikacin, and ofloxacin were present in the drug regimen of all patients. Average duration of the treatment was 18.5 months (range, 7-36). Over 76% of the patients responded to the treatment (negative smear and culture). Cure and probable cure were documented in seven (41.2%) and four (23.5%) of the patients, respectively. No failure in the treatment occurred when cycloserine was present in the treatment regimen.
Conclusion:
A majority of the MDR-TB patients in Iran can be cured with the use of appropriate treatment regimens. An even greater success could be achieved by providing more second-line drugs.
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