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1H NMR study on the conformation of bacitracin A in aqueous solution
N Kobayashi1, T Takenouchi, S Endo
1Institute of Applied Biochemistry, University of Tsukuba, Japan.
FEBS Letters
|June 29, 1992
Abstract:
The conformation of bacitracin A, a widely used cyclic dodecapeptide antibiotic in aqueous solution, has been investigated using 500 MHz 1H NMR and molecular modeling. Findings revealed that a region (residues 1-6) is folded over the cyclic ring, resulting in metal coordination sites, a thiazoline ring, and Glu4 and His10 being proximate to each other.