Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intraventricular conduction delay after bupropion overdose.

Steven C Curry1, John S Kashani, Frank LoVecchio

  • 1Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, Arizona 85006, USA.

The Journal of Emergency Medicine
|September 27, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Packed red blood cell transfusion affecting phosphatidylethanol concentration.

Clinical toxicology (Philadelphia, Pa.)·2026
Same author

Clinical decision support to aid in diagnosis of heparin-induced thrombocytopenia.

British journal of haematology·2026
Same author

COMMENTARY.

Annals of emergency medicine·2026
Same author

Racial and Ethnic Disparities Persist in Outcomes After the 2015 Severe Sepsis and Septic Shock Early Management (SEP-1) Bundle.

The Journal of emergency medicine·2026
Same author

Dementia Care Research and Psychosocial Factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Presenteeism Among Health Care Personnel With COVID-19.

JAMA network open·2025
Same journal

Unrecognized Temporomandibular Joint Dislocation After Intubation, A Case Report.

The Journal of emergency medicine·2026
Same journal

High-Flow Nasal Cannula Therapy for Apneic Oxygenation during Rapid Sequence Induction in the Emergency Department: A Systematic Review.

The Journal of emergency medicine·2026
Same journal

Mechanical Versus Manual Cardiopulmonary Resuscitation Causing Traumatic Cardiothoracic and Abdominal Injuries: A Meta-Analysis and Systematic Review of Randomized Trials.

The Journal of emergency medicine·2026
Same journal

Drip-and-Ship versus Mothership Model in Acute Ischemic Stroke: A Meta-Analysis Stratified by Stroke System Integration.

The Journal of emergency medicine·2026
Same journal

Response to: "Letter to the Editor Regarding Cervical Spine Clearance in Adult and Pediatric Trauma: A Systematic Review".

The Journal of emergency medicine·2026
Same journal

Ultrasound Characterization of the Distal Thigh Great Saphenous Vein Dimensions in Children and Adults: Implications for Peripheral Rescue Access.

The Journal of emergency medicine·2026
See all related articles

Bupropion overdose can cause QRS widening, a serious heart rhythm issue. This study confirms this link in patients with confirmed bupropion levels, highlighting a crucial diagnostic consideration.

Area of Science:

  • Cardiology
  • Clinical Toxicology
  • Pharmacology

Background:

  • Bupropion overdose is typically associated with tachycardia, agitation, and seizures.
  • Previous reports of QRS widening in bupropion overdose lacked confirmed plasma concentrations or exclusion of other causes.

Observation:

  • Two patients presented with confirmed bupropion overdose.
  • Elevated plasma bupropion concentrations were verified.
  • Comprehensive toxicology testing excluded other cardiotoxic ingestions.

Findings:

  • Bupropion overdose was definitively linked to QRS complex widening in these cases.
  • Findings support ex vivo data showing bupropion antagonizes cardiac voltage-gated sodium channels.
  • Bupropion's cardiotoxicity mechanism involves sodium channel blockade.

Related Experiment Videos

Implications:

  • Unexpected QRS widening in overdose cases should prompt consideration of bupropion toxicity.
  • This research reinforces the importance of analytical toxicology in overdose management.
  • Understanding bupropion's effect on cardiac sodium channels is critical for clinical toxicology.