Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Radiotherapy for unresectable hepatic malignancies.

Edgar Ben-Josef¹, Theodore S Lawrence

¹Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109-0010, USA. edgarb@med.umich.edu

Seminars in Radiation Oncology

|September 27, 2005

Summary

Recent advancements in radiotherapy offer new hope for managing unresectable liver tumors. High-dose radiation, guided by understanding radiation-induced liver disease (RILD) risks, shows improved survival rates for hepatic malignancies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Novel Adjuvant Chemoradiotherapy/Immunotherapy for Resected Biliary Cancer.

JAMA oncology·2025

Same author

Enhancing outcomes in medically inoperable early-stage NSCLC with gut-targeted antibiotics and stereotactic body radiotherapy: results from a randomized pilot study.

Journal for immunotherapy of cancer·2025

Same author

A phase 1 dual-dose escalation study of radiation and nab-paclitaxel in patients with unresectable and borderline resectable pancreatic cancer.

Cancer·2025

Same author

Evaluating the Safety and Efficacy of Adding Liver-Directed Radiation Therapy to Atezolizumab and Bevacizumab in Advanced Hepatocellular Carcinoma: A Single-Center Retrospective Cohort Analysis.

American journal of clinical oncology·2025

Same author

Long-term Outcomes of Definitive Chemoradiation With Proton Therapy for Treatment of Carcinoma of the Anal Canal: Combined Analysis of Two Prospective Trials.

International journal of radiation oncology, biology, physics·2025

Same author

Start Early and See Inflammatory; Late, Nothing Save RAVE: How to Appreciate Radiation Proctitis as a Continuum.

Gastro hep advances·2024

Area of Science:

Oncology
Radiotherapy
Hepatology

Background:

Hepatic malignancies, both primary and metastatic, pose a significant clinical challenge.
Many patients present with unresectable disease, lacking a standard treatment approach.

Purpose of the Study:

To review recent advancements in radiotherapy for managing hepatic malignancies.
To highlight how improved understanding of radiation dose and volume impacts treatment outcomes and toxicity.

Main Methods:

Review of recent literature on radiotherapy techniques for liver tumors.
Analysis of clinical trials and reported experiences with various radiotherapy modalities.

Main Results:

High-dose focal liver radiation, informed by dose-volume-RILD relationships, yields encouraging results.

Related Experiment Videos

A US phase II trial indicated a survival benefit correlating with radiation dose compared to historical data.

Favorable outcomes reported with moderate-dose external-beam radiotherapy, stereotactic hypofractionated radiotherapy, and radiopharmaceuticals.

Conclusions:

Radiotherapy is an increasingly important modality for liver cancer management.
Advances in understanding radiation effects allow for more effective and safer liver-directed radiation therapies.
Various radiotherapy approaches show promise for improving survival in unresectable hepatic malignancies.