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Updated: Aug 15, 2026

A Model of Chronic Nutrient Infusion in the Rat
Published on: August 14, 2013
Central administration of alloxan impairs glucose tolerance in rats
M Salkovic-Petrisic1, Z Lackovic, S Hoyer
1Department of Pharmacology, School of Medicine and Croatian Institute for Brain Research, University of Zagreb, Croatia. melitas@mef.hr
Abstract:
By means of oral glucose tolerance test (OGTT), we investigated glucose tolerance in rats pre-treated with intracerebroventricular and subcutaneous non-diabetogenic dose of betacytotoxic drug alloxan 7 days before OGTT. Being normoglycemic and normoinsulinemic pre-OGTT, at 30 minutes post-OGTT, alloxan intracerebroventricularly-treated rats had a lower glucose and a higher insulin plasma levels in comparison with controls or alloxan subcutaneously treated animals. Centrally administered alloxan seems to have brain related effect on the regulation of peripheral glucose tolerance and insulin secretion.
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