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Updated: Aug 15, 2026
Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
Direct autoradiographic evidence that rebamipide interacts with neutrophils in dextran sulfate sodium induced colitis
Masahiko Nakamura1, Tetsufumi Takahashi, Tsukasa Matsumoto
1Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. nakamuram@pharm.kitasato-u.ac.jp
Abstract:
To determine the effects of rebamipide during the early stages of colitits development, colitis was induced in rats by oral administration of dextran sulfate sodium for 3 or 7 days. The target sites of (3)H-rebamipide were examined by intra-aortic infusion of the radiolabeled compound followed by autoradiography. (3)H-rebamipide was localized in goblet cells in the colon of the control rat, whereas it accumulated in the cytoplasm of mesenchymal cells in dextran sulfate sodium treated rats, localized predominantly to polymorphonuclear leucocytes.
