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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
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Orthotopic Liver Transplantation in Rats
18:25

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Published on: July 1, 2012

Appendicitis among liver transplant recipients.

Peter L Abt1, Ibrahim Abdullah, Kathleen Korenda

  • 1Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
|September 27, 2005
PubMed
Summary

Appendicitis in liver transplant recipients is rare and presents differently than in the general population. Early diagnosis and surgery are crucial for positive outcomes in these immunocompromised patients.

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Area of Science:

  • Transplantation immunology
  • Gastrointestinal surgery
  • Clinical case series

Background:

  • Appendicitis is a common surgical emergency, but its presentation in liver transplant recipients is not well-documented.
  • Liver transplant recipients (LTRs) are immunocompromised, potentially altering their inflammatory responses.

Purpose of the Study:

  • To describe the clinical characteristics, presentation, and outcomes of appendicitis in liver transplant recipients.
  • To compare the presentation of appendicitis in LTRs to nonimmunosuppressed individuals.

Main Methods:

  • Retrospective review of 8 liver transplant recipients diagnosed with appendicitis.
  • Analysis of clinical data including presentation, laboratory findings, surgical intervention, and outcomes.

Main Results:

  • Appendicitis occurred between 3 weeks and 181 months post-liver transplantation (LT).
  • Most patients lacked leukocytosis, a common indicator in nonimmunosuppressed individuals.
  • Four patients had appendiceal perforation, with three presenting >3 days after symptom onset.
  • All patients underwent surgery and recovered without complications.

Conclusions:

  • Appendicitis can occur in LTRs, often presenting atypically without leukocytosis.
  • Prompt surgical management is essential for favorable outcomes in LTRs with appendicitis.
  • Further research is needed to understand the specific pathophysiology and optimize management strategies.