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Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
09:11

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

Published on: February 23, 2016

[Secondary stroke and its prevention in patients with arterial hypertension]

V A Parfenov, S V Gurak

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |September 28, 2005
    PubMed

    Insights

    Regular medication for hypertension and thrombosis significantly reduces secondary stroke and cardiac infarction risk in patients with arterial hypertension. Adherence to treatment, especially after physician consultation and in rehabilitation centers, improves prognosis.

    Area of Science:

    • Neurology
    • Cardiology
    • Geriatrics

    Background:

    • Ischemic stroke is a significant health concern, particularly in patients with arterial hypertension and cerebral atherosclerosis.
    • Secondary strokes carry a higher lethality and lead to more severe disability compared to initial events.
    • Arterial hypertension is a major risk factor for both ischemic stroke and cardiac infarction.

    Purpose of the Study:

    • To analyze the incidence and outcomes of secondary ischemic stroke in patients with arterial hypertension and cerebral atherosclerosis.
    • To evaluate the impact of regular antihypertensive and antithrombotic medication on morbidity and mortality in these patients.
    • To identify prognostic factors influencing the course of ischemic stroke and associated cardiovascular events.

    Main Methods:

    • Analysis of 650 patients with ischemic stroke, arterial hypertension, and cerebral atherosclerosis.
    • Follow-up studies of patients with secondary stroke (n=50) and primary stroke survivors (n=90) with arterial hypertension.
    • Comparison of outcomes between patients receiving regular medication and those not adhering to treatment.

    Main Results:

    • Secondary ischemic stroke occurred in 25% of cases, with 1.5 times higher lethality and more severe disability than initial strokes.
    • In a 1-year follow-up, secondary stroke patients had high rates of recurrent stroke (28%), cardiac infarction (8%), and mortality (22%).
    • Regular antihypertensive and antithrombotic medication significantly reduced morbidity and mortality from stroke and cardiac infarction. Primary stroke survivors with regular treatment had significantly lower secondary stroke incidence (8.8%) and mortality (2.2%).

    Conclusions:

    • Secondary ischemic stroke is a serious complication in patients with arterial hypertension and cerebral atherosclerosis.
    • Regular intake of antihypertensive and antithrombotic medications is a favorable prognostic factor, significantly reducing adverse cardiovascular events.
    • Patient education and adherence to treatment, particularly in rehabilitative settings, are crucial for improving outcomes and reducing mortality.

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