Related Experiment Video
Updated: Aug 15, 2026

Pediatric Animal Model of Extracorporeal Cardiopulmonary Resuscitation After Prolonged Circulatory Arrest
Published on: May 26, 2023
[Usefulness of Cochrane Collaboration for pediatric cardiology]
Javier González-de Dios1, Albert Balaguer-Santamaría, Carlos Ochoa-Sangrador
1Departamento de Pediatría, Hospital Universitario San Juan, Universidad Miguel Hernández, Alicante, Spain. gonzalez_jav@gva.es
Insights
Cochrane systematic reviews in pediatric cardiology are infrequent and often lack sufficient evidence for clinical practice. Many important pediatric heart conditions lack reviews, highlighting a gap in evidence-based care.
Area of Science:
- Cardiology
- Evidence-Based Medicine
- Systematic Reviews
Background:
- The Cochrane Collaboration provides systematic reviews to support medical decision-making.
- Systematic reviews are crucial for evidence-based practice in medicine.
Purpose of the Study:
- To analyze the availability and quality of Cochrane systematic reviews in pediatric cardiology.
- To identify gaps in evidence-based reviews for pediatric cardiovascular conditions.
Main Methods:
- Systematic search and analysis of Cochrane Collaboration's systematic reviews.
- Categorization of reviews by relevant Cochrane Review Groups.
- Assessment of the scope and focus of pediatric cardiology reviews.
Main Results:
- Only 20 systematic reviews were identified in pediatric cardiology.
- Reviews primarily focused on patent ductus arteriosus, hypotension in preterm infants, and Kawasaki disease.
- Limited quality of clinical trials in some reviews (e.g., rheumatic fever, childhood obesity).
- No systematic reviews found for critical areas like heart failure, shock, hypertension, congenital heart disease, or arrhythmias.
- Many pediatric therapies lack supportive evidence.
Conclusions:
- Systematic reviews in pediatric cardiology are infrequent and often of limited quality or scope.
- There is a significant lack of evidence-based reviews for major pediatric cardiovascular conditions.
- Clinical practice in pediatric cardiology often relies on therapies without strong supporting evidence.
- Further research and systematic reviews are urgently needed for key pediatric cardiology topics.
Abstract:
The Cochrane Collaboration provides growing and readily accessible resources to help ensure that medical decision-making is based on detailed, methodical, and up-to-date reviews of the best available evidence. We analyzed systematic reviews in the field of pediatric cardiology published by the Cochrane Collaboration's 50 Collaborative Review Groups. We found a total of 20 systematic reviews: 13 published by the Cochrane Neonatal Group, 6 by the Cochrane Heart Group, and 1 by the Cochrane Peripheral Vascular Disease Group. Systematic reviews in pediatric cardiology appear infrequently. They only concern evidence-based decision-making in the therapeutic management of patent ductus arteriosus and arterial hypotension in preterm infants, and in the management of children with Kawasaki disease. The quality of the clinical trials contained in the systematic reviews of acute rheumatic fever or obesity in children is limited. Consequently, the reviewers' conclusions provide an inadequate basis for inferring probable effects in clinical practice. In pediatric cardiology, many therapies continue to be used without supportive evidence. We found no systematic reviews of important cardiologic topics in childhood such as heart failure, shock, hypertension, congenital cardiopathy, and arrhythmia. Clinical practice guidelines complement systematic reviews, which can recommend only strategies that are supported by strong evidence or suggest further research when scientific evidence is inadequate.
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Cardiomyopathy V: Interprofessional Care
