Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The microbial pan-genome.

Duccio Medini1, Claudio Donati, Hervé Tettelin

  • 1Immunobiological Research Institute of Siena (IRIS), Chiron Vaccines, via Fiorentina 1, 53100 Siena, Italy.

Current Opinion in Genetics & Development
|September 28, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linking microbial function and remote sensing for understanding drylands.

Trends in ecology & evolution·2026
Same author

Genomic and Ecological Flexibility Shape the Global Distribution of a Black Fungus.

Environmental microbiology·2026
Same author

Transcriptional regulation of the pneumococcal capsule can dictate serotype-specific infection.

Nature communications·2026
Same author

Correction for Bhavana et al., "A group B <i>Streptococcus</i> indexed transposon mutant library to accelerate genetic research on an important perinatal pathogen".

Microbiology spectrum·2026
Same author

Highly compartmentalized microbiomes in blueberry microhabitats.

Frontiers in microbiology·2026
Same author

Multispecies transcriptomics reveals influenza A virus modulation of <i>Streptococcus pneumoniae</i> EF3030 infection in human lung epithelium and murine lung.

mSphere·2026
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

Bacterial species are best described by their pan-genome, not just a single genome. This pan-genome includes core genes and a vast collection of dispensable genes, highlighting the extensive genetic diversity within species.

Area of Science:

  • Bacterial genomics
  • Microbial evolution
  • Bioinformatics

Background:

  • Genomic era has not fully defined bacterial species description.
  • New genes are continually discovered in bacterial species, even after sequencing multiple strains.
  • Mathematical modeling suggests extensive gene discovery with increased sequencing.

Purpose of the Study:

  • To address how genomics can comprehensively describe a bacterial species.
  • To introduce the concept of the pan-genome for bacterial species definition.
  • To highlight the scale of genetic diversity within bacterial species.

Main Methods:

  • Analysis of experimental genomic data from multiple bacterial strains.
  • Application of mathematical modeling to predict gene discovery rates.

Related Experiment Videos

  • Definition and conceptualization of the bacterial pan-genome.

    • Main Results:

    • Bacterial species cannot be fully described by single genomes.
    • The pan-genome, comprising core and dispensable genomes, offers a more complete description.
    • The dispensable genome contains numerous unique and shared genes, vastly expanding species' genetic repertoire.

    Conclusions:

    • A bacterial species is best represented by its pan-genome.
    • The pan-genome size can be orders of magnitude larger than any single genome.
    • Understanding the pan-genome is crucial for describing bacterial genetic diversity.