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Related Experiment Videos

Conditioned immunopharmacologic effects on cell-mediated immunity.

R Ader1, N Cohen

  • 1Department of Psychiatry, University of Rochester School of Medicine and Dentistry, New York, NY 14642.

International Journal of Immunopharmacology
|April 1, 1992
PubMed
Summary
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Behavioral changes can alter immune responses. This review explores how classical conditioning, using stimuli like stress, can modify cell-mediated immunity, including immune reactions in transplants and delayed hypersensitivity.

Area of Science:

  • Neuroimmunology
  • Behavioral immunology
  • Psychoneuroimmunology

Background:

  • Evidence links the brain and immune system.
  • Behaviorally induced immune alterations are a key area of study.
  • The brain's influence on immune function is increasingly recognized.

Purpose of the Study:

  • To review the role of unconditioned stimuli (UCSs) in classical conditioning of immune responses.
  • To examine how immunopharmacologic agents, stress, and antigenic stimuli condition immune reactivity.
  • To focus on the modulation of cell-mediated immunity through behavioral conditioning.

Main Methods:

  • Review of studies using classical conditioning paradigms.
  • Analysis of unconditioned stimuli (UCSs) such as immunopharmacologic agents, stress, and antigens.

Related Experiment Videos

  • Examination of conditioned suppression and enhancement of immune responses.

    • Main Results:

    • Classical conditioning can suppress or enhance cell-mediated immune reactions.
    • Specific UCSs can be used to condition immune responses.
    • Host-vs-graft, graft-vs-host, and delayed type hypersensitivity are affected.

    Conclusions:

    • Behavioral conditioning is a viable method to modulate immune responses.
    • The brain-immune axis can be influenced by learned associations.
    • Further research into psychoneuroimmunology can reveal therapeutic potentials.