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Nutrition and cellular immunity.

R A Good1, E Lorenz

  • 1Department of Pediatrics, All Children's Hospital, University of South Florida, St. Petersburg.

International Journal of Immunopharmacology
|April 1, 1992
PubMed
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Adequate nutrition, particularly zinc, is vital for immune function. Moderate calorie restriction, with sufficient micronutrients, extends lifespan and enhances immunity in animals, preventing age-related diseases.

Area of Science:

  • Immunology
  • Nutrition Science
  • Gerontology

Background:

  • Nutritional deficiencies profoundly impair immune function, especially in developing countries.
  • Zinc is critical for T- and B-cell development and function.
  • Protein-calorie malnutrition often leads to zinc deficiency, impacting cellular immunity.

Purpose of the Study:

  • To investigate the influence of nutrition on immune function in animals and humans.
  • To explore the paradox of nutritional restriction enhancing immune responses in some contexts.
  • To understand how chronic energy restriction impacts lifespan and age-related diseases.

Main Methods:

  • Investigated animal models and human studies over two decades.
  • Examined the role of zinc in cellular immunity.

Related Experiment Videos

  • Assessed the effects of 40% chronic energy restriction on lifespan and immune function in various animal strains.

    • Main Results:

    • Zinc deficiency impairs T- and B-cell functions; zinc supplementation can correct immune deficits in malnourished children.
    • Moderate nutritional restriction, with adequate essential nutrients, extends lifespan in mice and rats.
    • Chronic energy restriction maintains immune function and prevents cancers and autoimmune diseases in aging animals.
    • Undernutrition without malnutrition down-regulates cellular proliferation and cell turnover.

    Conclusions:

    • Zinc is essential for maintaining robust immune responses.
    • Calorie restriction, when balanced with adequate micronutrients, is a potent intervention for extending lifespan and healthspan.
    • Nutritional strategies can modulate immune function and combat age-related diseases.