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Soy isoflavones, body composition, and physical performance.

Linda Kok1, Sanne Kreijkamp-Kaspers, Diederick E Grobbee

  • 1The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.

Maturitas
|September 28, 2005
PubMed
Summary

Soy isoflavones did not improve body composition or physical performance in postmenopausal women. This study found no benefits for aging women seeking alternatives to hormone therapy.

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Area of Science:

  • Gerontology and Nutritional Science
  • Reproductive Endocrinology

Background:

  • Aging is associated with physiological changes and increased chronic disease risk.
  • Declining estradiol post-menopause is linked to aging risks; hormone therapy (HT) has side effects.
  • Alternative strategies to mitigate aging-related health decline are needed.

Purpose of the Study:

  • To investigate the effects of soy isoflavones on body composition and physical performance in postmenopausal women.
  • To evaluate soy isoflavones as a potential alternative to hormone therapy for managing aging-related changes.

Main Methods:

  • A 12-month double-blind randomized trial involving 202 postmenopausal women (aged 60-75 years).
  • Comparison of daily soy protein (99mg isoflavones) versus milk protein (placebo).

Related Experiment Videos

  • Assessment of endpoints including body composition (BMI, waist-to-hip ratio) and physical performance (handgrip strength, functional status).

    • Main Results:

    • No significant changes in body mass index or waist-to-hip ratio were observed between groups.
    • Handgrip strength showed no statistically significant difference between the soy and placebo groups.
    • Self-reported functional status and physical performance showed slight improvements in both groups, with no inter-group differences.

    Conclusions:

    • The study findings do not support the efficacy of soy isoflavones in improving body composition.
    • Soy isoflavones did not demonstrate favorable effects on physical performance in the studied postmenopausal population.
    • This research suggests soy isoflavones are not an effective alternative for mitigating age-related declines in body composition and physical function.