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Related Experiment Videos

Development of a biologically relevant dermal sampler.

F E Lindsay1, S Semple, A Robertson

  • 1Institute of Occupational Medicine, Edinburgh, EH14 4AP, Scotland, UK.

The Annals of Occupational Hygiene
|September 28, 2005
PubMed
Summary
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A new Institute of Occupational Medicine (IOM) dermal sampler effectively measures volatile agent exposure, offering a more biologically relevant metric than traditional methods like activated charcoal cloth (ACC) patches.

Area of Science:

  • Occupational health
  • Environmental science
  • Analytical chemistry

Background:

  • Current methods for measuring dermal exposure to volatile agents are inadequate.
  • Dermal exposure is a significant route for volatile agent uptake.
  • Accurate measurement of dermal exposure is crucial for occupational health risk assessment.

Purpose of the Study:

  • To develop and evaluate a prototype Institute of Occupational Medicine (IOM) dermal sampler for measuring volatile agent exposure.
  • To compare the performance of the IOM dermal sampler with activated charcoal cloth (ACC) for toluene exposure measurement.
  • To assess the biological relevance of the IOM dermal sampler compared to existing methods.

Main Methods:

  • Development of a prototype IOM dermal sampler with adsorbent, permeable membrane, and impervious backing.

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  • Laboratory evaluations including spray, pour, and immersion tests under controlled conditions.
  • Field evaluations with simultaneous inhalation exposure measurements and comparison with ACC patches.

    • Main Results:

    • The prototype IOM dermal sampler responded to concentration rather than surface mass.
    • Field studies indicated suitability for measuring dermal exposure, despite high membrane permeation rates.
    • The IOM sampler demonstrated a significant difference in calculating body burden compared to ACC patches (1.5% vs. 95%).

    Conclusions:

    • The prototype IOM dermal sampler is the first practical device to mimic skin uptake of volatile agents.
    • The sampler provided reproducible results in laboratory and field trials, offering a more biologically relevant exposure metric.
    • Future research should focus on less permeable membranes and higher capacity adsorbents to improve sampler performance.