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Related Experiment Videos

Tuberculous meningitis and HIV.

Sunil Karande1, Vishal Gupta, Madhuri Kulkarni

  • 1Division of Pediatric Neurology, Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India. karandesunil@yahoo.com

Indian Journal of Pediatrics
|September 28, 2005
PubMed
Summary

Anemia (Hb < 8 gm/dl) was the only factor linked to HIV infection in children with tuberculous meningitis (TBM). HIV co-infection did not impact in-hospital outcomes for these TBM patients.

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Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neurology

Background:

  • Tuberculous meningitis (TBM) is a severe form of tuberculosis affecting the central nervous system.
  • HIV co-infection is a significant concern in pediatric TBM, potentially influencing disease presentation and outcomes.
  • Understanding factors associated with HIV status in TBM is crucial for targeted management.

Purpose of the Study:

  • To identify clinical, demographic, laboratory, and radiological factors associated with HIV infection in children diagnosed with TBM.
  • To determine if HIV co-infection affects in-hospital outcomes (disability or death) in pediatric TBM cases.

Main Methods:

  • A prospective, hospital-based study enrolled 123 children (1 month to 12 years) with TBM from May 2000 to August 2003.
  • Data collected included demographic factors, clinical and neurological features, cerebrospinal fluid parameters, and radiological findings.

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  • Statistical analysis assessed the relationship between 35 features and HIV-infected status, as well as in-hospital outcomes.

    • Main Results:

    • Eight (6.5%) of the 123 TBM cases were HIV-infected.
    • Children with HIV co-infection were significantly more likely to have low hemoglobin (Hb < 8 gm/dl) on both bivariate and multivariate analyses (P=0.001 and P=0.008, respectively).
    • No significant difference in in-hospital outcomes (disabled survivor or death) was observed between HIV-infected and HIV-uninfected TBM groups.

    Conclusions:

    • Low hemoglobin (Hb < 8 gm/dl) is the sole identified factor associated with HIV-infected status in children with TBM.
    • HIV co-infection does not appear to influence the in-hospital outcome for pediatric patients with tuberculous meningitis.