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Benign recurrent intrahepatic cholestasis

V Gupta1, M Kumar, Baldev D Bhatia

  • 1Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Indian Journal of Pediatrics
|September 28, 2005
PubMed

Insights

Benign recurrent intrahepatic cholestasis (BRIC) is a rare liver condition causing recurring jaundice in children. This case highlights BRIC in a 9-year-old Indian boy, a presentation previously unreported in this population.

Area of Science:

  • Hepatology
  • Pediatric Gastroenterology

Background:

  • Benign recurrent intrahepatic cholestasis (BRIC) is a rare genetic disorder characterized by intermittent cholestasis.
  • It typically manifests in infancy or early childhood with recurrent jaundice, but without progression to chronic liver disease.

Observation:

  • This report details an unusual case of BRIC in a 9-year-old boy from India.
  • The patient experienced recurrent jaundice episodes starting from 1 year of age.

Findings:

  • This is the first reported case of BRIC in an Indian child.
  • The clinical presentation aligns with established BRIC characteristics, including recurrent jaundice without progressive liver damage.

Implications:

  • This case expands the known geographical and demographic spectrum of BRIC.
  • It underscores the importance of considering BRIC in pediatric cholestasis, even in regions where it has not been previously documented.
  • Further research into potential genetic variations or environmental factors in Indian populations may be warranted.

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