Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Remembering the cell fate during cellular differentiation.

Guo-Ling Zhou1, Li Xin, De-Pei Liu

  • 1National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, PR China.

Journal of Cellular Biochemistry
|September 28, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ACAD8 deficiency promotes pathological cardiac hypertrophy in response to pressure overload by regulating histone isobutyrylation.

Nature communications·2026
Same author

Metabolomics Identified Caloric Restriction-associated Glycerophospholipid Alterations in ApoE-/- Mice.

Genomics, proteomics & bioinformatics·2026
Same author

Redox rhythms promote fitness by modulating ageing-dependent reprogramming.

Nature metabolism·2026
Same author

Correction to: Targeting PDE4B (Phosphodiesterase-4 Subtype B) for Cardioprotection in Acute Myocardial Infarction via Neutrophils and Microcirculation.

Circulation research·2026
Same author

Enhanced B cell electroporation efficiency via inhibition of DNA-induced apoptosis and pyroptosis with pan-caspase inhibitor.

Molecular therapy. Methods & clinical development·2025
Same author

Novel Mouse Model of Coronary Atherosclerosis With Myocardial Infarction: Insights Into Human CAD.

Circulation research·2025

Cells possess inherent mechanisms for remembering gene expression states during differentiation. This cellular memory, potentially involving stochastic gene expression and epigenetic marks, ensures developmental stability across cell divisions.

Area of Science:

  • Cellular biology
  • Epigenetics
  • Developmental biology

Background:

  • Higher eukaryotes exhibit diverse cell types, each with unique gene expression patterns despite sharing a common genome.
  • Cellular differentiation involves establishing and maintaining specific gene expression patterns through cell division.
  • Stable differentiation and development necessitate cellular mechanisms for remembering expression states.

Purpose of the Study:

  • To hypothesize a cellular memory mechanism responsible for maintaining gene expression states.
  • To explore the role of stochastic gene expression in cell-cell variation during differentiation.
  • To elucidate how epigenetic modifications and mitotic inheritance contribute to cellular memory.

Main Methods:

  • Speculative hypothesis on cellular memory mechanisms.

Related Experiment Videos

  • Consideration of stochastic gene expression as a basis for cell-cell variation.
  • Analysis of the role of histone modifications and regulatory sequences in modulating expression stochasticity.
  • Examination of S-phase-dependent gene activation and epigenetic marks in state discrimination.
  • Postulation of mitotic memory mechanisms for transmission of expression states.

    • Main Results:

    • Cell-cell variation in differentiation may arise from inherent stochastic gene expression.
    • Histone evolution and regulatory sequences influence expression stochasticity parameters.
    • Epigenetic marks and S-phase-dependent gene activation differentiate active and repressive states.
    • Mitotic memory mechanisms enable the inheritance of expression states through cell divisions.

    Conclusions:

    • Cells possess inherent mechanisms for maintaining specific gene expression patterns.
    • Stochastic gene expression, modulated by epigenetic factors, plays a crucial role in cellular memory.
    • Mitotic inheritance of epigenetic states ensures the stability of differentiated cell types.